5. Fibrinolytic Lymphostimulation In Treatment Of Diabetic Angiopathies

Authors

  • S.D. Aliyev Azerbaijan medical university, department of pathological physiology, Baku, Azerbaijan
  • A.J. Mamedzade Azerbaijan medical university, department of pathological physiology, Baku, Azerbaijan
  • M.Kh. Aliyev Azerbaijan medical university, department of pathological physiology, Baku, Azerbaijan
  • Sh.M. Huseynova Azerbaijan medical university, department of pathological physiology, Baku, Azerbaijan
  • U.I. Ahmedzade Azerbaijan medical university, department of pathological physiology, Baku, Azerbaijan

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Abstract

Objective: Study of lipid peroxidation disorder, lymph coagulation and lymphatic tissue drainage, their correction in experimental diabetes mellitus.

Methods: Studies were carried out on 33 rabbits, on a model of diabetes mellitus. In 16 rabbits of the control group, after modeling of alloxane diabetes mellitus, a sucking therapy was performed, and in 17 rabbits of the experimental group, the sucking therapy included intravenous administration of urokinase-medac in a dose of 100,000 U for 7 days. Values of LPO and clotting of lymph as well as lymphatic tissue drainage were investigated by conventional methods.

Results: Simula-tion of diabetes mellitus in rabbits contributed to increase of clotting potential of lymph with background of activation of lipid peroxidation and reduction of activity of lymph fibrinolysis, with suppression of drainage function of lymphatic system. After administration of medakurokinase, the coagulation potential of the lymph and the intensity of lipoperoxidationwere significantly reduced. At the same time, the content of dienecon-jugates (DC) and malonicdialdehyde (MDA) was significantly reduced, and during 30 days of the study, markers of activation of intravascular clotting of lymph were not determined. All this was accompanied by a very pronounced increase in the flow rate of lymph from the drained thoracic duct, exceeding the initial and control levels by 57.1% and 94.1%, respectively (p < 0.001).

Conclusion: the inclusion of medakurokinase in the complex of sugarlowering therapy contributed not only to a marked reduction of clotting potential of lymph and activation of lipoperoxidation, but also very much increased lymphatic tissue drainage. tissue drainage

Keywords

diabetic angiopathy, lymph, coagu-lation, lipoperoxidation

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Published

2020-10-01

Issue

No. 3 (2020)

Section

Статьи