А.И. Сайлыбаева

https://orcid.org/0000-0002-1489-3837

Найдено статей: 4

  • Periodontitis As A Possible Cause Of Chronic Heart Failure (Выпуск № 3, 2025)

    Dana Yessimgalikyzy, R. Aipov Baurzhan, R. Kassiyet Nurlan, Aldanysh Zhumazhan, T. Taukelova Ainur, K. Saltanat Jetybayeva, Islambek Laiskanov, Aliya Sailybayeva, S. Bekbosynova Makhabbat, R. Kushugulova Almagul
    2025-09-30
    56–63
    Аннотация

    Background. The objective of this study was to investigate the prevalence of periodontitis in patients with chronic heart failure, as well as to characterize the microbiological profile of periodontitis across different chronic heart failure phenotypes. The objective is to analyze the link between oral health and heart disease.

    Materials and Methods. A cohort of 98 chronic heart failure patients (mean age 62.22 ± 8.62 years, 69 men) was assessed through comprehensive cardiological and periodontal examinations. Patients were categorized into heart failure with reduced ejection fraction, mildly reduced ejection fraction, and preserved ejection fraction. Periodontal parameters, including probing pocket depth, clinical attachment loss, and bleeding on probing were evaluated. Microbiological and statistical analyses were conducted.

    Results. Severe periodontitis (Stage C) was identified in 30% of patients, while 48% had moderate periodontitis (Stage B). Patients with chronic heart failure with reduced ejection fraction exhibited the highest prevalence of severe periodontitis, with a significant correlation between increased probing pocket depth and reduced ejection fraction. Candida species abundance was associated with lower ejection fraction (p≤0.0Y) and advanced periodontitis (p≤0.0X). Elevated NT-proBNP levels (1121.00–7611.00 pg/mL) correlated with Streptococcus mitis prevalence, while C-reactive protein levels (up to 2.35 mg/dL) were highest in patients with Klebsiella pneumoniae.

    Conclusion. The study highlights a strong association between periodontal disease, microbial dysbiosis, and CHF. Findings suggest that oral microbial imbalances, particularly involving Candida, Streptococcus mitis, and Klebsiella pneumoniae, contribute to systemic inflammation and cardiovascular complications.

    Ключевые слова

    dental health surveys, gingiva pathology, heart failure, inflammation, periodontal index

  • Features Of Risk Factors For The Development Of Atherosclerosis-Associated Cardiovascular Diseases In The Kazakhstani Population. Ethnonational Aspect (Выпуск № 3, 2025)

    Makhabbat Bekbossynova, Tatyana Ivanova-Razumova, Aliya Sailybayeva, Sadyk Khamitov, Kamila Akzholova
    2025-09-30
    43–55
    Аннотация

    Background. Atherosclerosis-associated cardiovascular diseases exhibit significant ethnic and regional variability in risk factors. Kazakhstan’s high cardiovascular disease mortality rates necessitate population-specific profiling, particularly given urban-rural disparities and lifestyle differences unique to Central Asia.

    Methods. This cross-sectional study (2023–2024) analyzed 368 Kazakhstani adults stratified by European Atherosclerosis Society risk tiers: low (n=67), high (n=127), and very high risk (very high-risk group, n=174). Assessments included lipid profiles (low density lipoprotein, high density lipoprotein, and apolipoprotein B to apolipoprotein A ratio), lifestyle factors (smoking, diet, physical activity), and residence (urban/rural). Statistical analyses employed multiclass logistic regression (MNLogit) with FDR-adjusted p-values.

    Results. Age (OR=8.01, 95% CI:4.40–14.58, p<0.001), male sex (OR=3.27, CI:1.82–5.88), and smoking (OR=7.19, CI:1.52–34.15) were strongly associated with very high-risk group. Rural residents faced 2.6-fold higher very high-risk group odds (CI:1.52–5.68, p=0.002) versus urban counterparts. Protective effects emerged for physical activity (OR=0.03, CI:0.004–0.32) and female sex (High-Density Lipoprotein: +8.1 mg/dL vs. males, p<0.001). No alcohol association was observed (p=0.836).

    Conclusion. A thorough study of the gender aspect of the development of atherosclerotic pathology is required. Physical activity has a strong protective effect. It is interesting that, according to the comparative analysis of binary variables, rural residents have a higher risk of developing atherosclerosis.

    Ключевые слова

    atherosclerosis, cardiovascular risk factors, Kazakhstan, urban-rural disparities, lipid metabolism, preventive cardiology

  • Correlation between apolipoprotein b/a1 and the risk of metabolic-related fatty liver disease depending on the lipid profile (Выпуск № 1, 2025)

    M. Bekbossynova, G. Myrzakhmetova, S. Seitkasym, A. Sailybaeva, S. Khamitov, G. Daniyarova, K. Akzholova
    2025-03-31
    29–36
    Аннотация

    Background. The aim of this study was to investigate the relationship between the Apolipoprotein B/Apolipoprotein A1 ratio and the risk of metabolically associated fatty liver disease, considering lipid profile variations and determine whether the Apolipoprotein B/Apolipoprotein A1 ratio can serve as an independent predictor of metabolically associated fatty liver disease and its associated cardiovascular risks.

    Methods. A total of 377 patients diagnosed with cardiovascular disease and coexisting metabolically associated fatty liver disease were stratified into high-risk and very high-risk groups based on established clinical and imaging criteria. Lipid profiles, Apolipoprotein B, and Apolipoprotein A1 levels were measured, and their associations with cardiovascular and metabolic parameters were analyzed using correlation and regression models.

    Results. The findings reveal a strong positive correlation between Apolipoprotein B levels and atherogenic lipid markers such as low-density lipoproteins cholesterol and total cholesterol, as well as a moderate correlation with triglycerides. In contrast, Apolipoprotein A1 demonstrated a strong positive association with high-density lipoproteins cholesterol and an inverse correlation with metabolic indicators such as Hemoglobin A1c and glucose, suggesting a potential protective role. The Apolipoprotein B/Apolipoprotein A1 ratio emerged as a more accurate predictor of cardiovascular and metabolic risk than traditional lipid ratios. Furthermore, the Apolipoprotein B/Apolipoprotein A1 ratio was significantly associated with the presence and severity of metabolically associated fatty liver disease, reinforcing its potential utility as a biomarker for metabolic liver disease.

    Conclusion. This study highlights the clinical relevance of incorporating apolipoprotein measurements into the routine assessment of individuals at risk for metabolic and cardiovascular disease.

    Ключевые слова

    Apolipoprotein B, Apolipoprotein A1, metabolic-associated fatty liver disease, cardiovascular disease, lipid metabolism, dyslipidemia, risk assessment

  • Особенности течения неалкогольной жировой болезни печени при сахарном диабете 2 типа и нарушении толерантности к глюкозе (Выпуск № 2, 2024)

    М. С. Бекбосынова, Г. Ш. Мырзахметова, Ш. К. Сейткасым, А.И. Сайлыбаева, С.Р. Хамитов, Ж. О. Оралбекова, Г. Д. Даниярова
    2024-06-28
    39–49
    Аннотация

    Фон. Неалкогольная жировая болезнь печени и сахарный диабет 2 типа или нарушение толерантности к глюкозе являются распространёнными заболеваниями с высоким риском развития сердечно-сосудистых заболеваний, основной причиной инвалидности и смерти. Наша цель - разработать новые методы скрининга, профилактики и лечения сердечно-сосудистых заболеваний у пациентов с вышеуказанными заболеваниями. Методы и методология. Данное исследование является одно-центровым, открытым, неконтролируемым, диагностическим. В период с 2023 по февраль 2024 года в Кардиологическом центре «Университетский медицинский центр» Корпоративного фонда отобрано 216 пациентов с сердечно-сосудистыми заболеваниями и сопутствующей неалкогольной жировой болезнью печени, сахарным диабетом 2 типа и нарушением толерантности к глюкозе.

    Результаты. У всех обследованных больных с сердечно-сосудистыми заболеваниями и сопутствующей неалкогольной жировой болезнью печени выявлено повышение активности печеночных ферментов. Показатели липидного профиля крови достоверно превышали оптимальные уровни для пациентов с сердечно-сосудистыми заболеваниями. Также отмечено достоверное увеличение ферментов печени, С-реактивного белка, триглицеридов и малого липопротеина у пациентов с сердечно-сосудистыми заболеваниями и неалкогольной жировой болезнью печени в сочетании с сахарным диабетом 2 типа и нарушением толерантности к глюкозе. Выводы. Анализ активности ферментов печени, С-реактивного белка, глюкозы и липидограммы показал достоверное увеличение этих показателей у пациентов с сердечно-сосудистыми заболеваниями и неалкогольной жировой болезнью печени, особенно при наличии сахарного диабета 2 типа и нарушения толерантности к глюкозе. У всех обследованных больных наблюдалось повышение активности ферментов печени и уровня липидов, что свидетельствует о влиянии этих заболеваний на печень и обмен веществ.

    Ключевые слова

    Неалкогольная жировая болезнь печени, Сахарный диабет 2 тип, толерантность к глюкозе, Сердечно-сосудистые заболевания, Метаболический синдром