М. С. Бекбосынова
https://orcid.org/0000-0003-2834-617X
Найдено статей: 9
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Cardiorespiratory Fitness And Its Role In Managing Atrial Fibrillation. A Literature Review (Выпуск № 3, 2025)
Akmaral Beisenbayeva, Makhabbat Bekbossynova, Feruza Bekmetova, Uldana Aleushinova, Akhmetbek Abdrakhmanov, Ayan Abdrakhmanov2025-09-3084–95Аннотация
Background. Atrial Fibrillation is a prevalent cardiac arrhythmia associated with irregular heartbeats, posing significant health risks. The purpose of the study is literature review seeks to explore the intricate relationship between cardiorespiratory endurance and Atrial Fibrillation, shedding light on how cardiorespiratory parameters can serve as essential markers for assessing physical activity levels.
Materials and methods. The search was conducted using electronic databases, particularly PubMed, Google Scholar, and Scopus. Titles and abstracts of identified studies were screened for relevance, and full-text articles were reviewed for eligibility. The following keywords were used in the search: atrial fibrillation, cardiorespiratory fitness, maximal oxygen consumption, cardiovascular mortality. The search depth is 25 years.
Results. Physical activity adherence lowers overall and cardiovascular mortality in Atrial Fibrillation patients. Tailored exercise regimens alleviate Atrial Fibrillation symptoms, improve heart rate control, and enhance well-being. Standardizing cardiorespiratory testing protocols is crucial for consistent comparisons. Various testing methods, including treadmill protocols and cycle ergometers, offer insights into Cardiorespiratory fitness. Differences between treadmill and cycle ergometer outcomes warrant careful interpretation. Normative values vary across populations, influenced by physical activity, geography, genetics, and testing modalities.
Conclusions. Integrating cardiorespiratory testing into AF management enhances diagnosis and personalized interventions, contributing to a nuanced approach in addressing this prevalent cardiac condition.
Ключевые слова
Atrial fibrillation, Cardiorespiratory fitness, Maximal oxygen consumption, Cardiovascular mortality, Ventilatory anaerobic threshold
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Six-Minute Walk Test As A Tool For Assessing Physical Activity In Patients With Heart Failure (Выпуск № 3, 2025)
S. Bekbossynova Makhabbat, R. Kushugulova Almagul, K. Jetybayeva Saltanat, T. Tauekelova Ainur, S. Duisenbina Zhadyra, Aida Zholdybaeva2025-09-3064–72Аннотация
Background. Heart failure is one of the most significant medical problems of our time, which is associated with the increase in the prevalence of the disease over the past decade. The six-minute walk test is a simple, accessible, and informative tool for assessing the physical activity of patients with heart failure. The test results correlate with peak oxygen consumption and can be used to monitor the effectiveness of rehabilitation programs. The aim of the study is to evaluate the effectiveness of the six-minute walk test as a tool for measuring the level of physical activity and functional status in patients with heart failure, and to determine its correlation with clinical indicators and quality of life in this category of patients.
Materials and methods. In this study, conducted on the basis of the UMC "Heart Center" Astana, Kazakhstan, private institution "National Laboratory Astana", data of patients with heart failure of class I-IV according to a special classification were analyzed. The main objective of the study was to evaluate the effectiveness of the test as a tool for monitoring physical activity and functional status of patients.
Results. The results showed that the test is a reliable method for assessing the dynamics of physical capabilities and can be used to individualize rehabilitation programs.
Conclusion. The 6MWT remains an important component of clinical practice, helping to optimize functional outcomes and improve the quality of life of patients with heart failure.
Ключевые слова
heart failure, six-minute walk test (6MWT), physical activity, cardiac rehabilitation, functional status, quality of life
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Periodontitis As A Possible Cause Of Chronic Heart Failure (Выпуск № 3, 2025)
Dana Yessimgalikyzy, R. Aipov Baurzhan, R. Kassiyet Nurlan, Aldanysh Zhumazhan, T. Taukelova Ainur, K. Saltanat Jetybayeva, Islambek Laiskanov, Aliya Sailybayeva, S. Bekbosynova Makhabbat, R. Kushugulova Almagul2025-09-3056–63Аннотация
Background. The objective of this study was to investigate the prevalence of periodontitis in patients with chronic heart failure, as well as to characterize the microbiological profile of periodontitis across different chronic heart failure phenotypes. The objective is to analyze the link between oral health and heart disease.
Materials and Methods. A cohort of 98 chronic heart failure patients (mean age 62.22 ± 8.62 years, 69 men) was assessed through comprehensive cardiological and periodontal examinations. Patients were categorized into heart failure with reduced ejection fraction, mildly reduced ejection fraction, and preserved ejection fraction. Periodontal parameters, including probing pocket depth, clinical attachment loss, and bleeding on probing were evaluated. Microbiological and statistical analyses were conducted.
Results. Severe periodontitis (Stage C) was identified in 30% of patients, while 48% had moderate periodontitis (Stage B). Patients with chronic heart failure with reduced ejection fraction exhibited the highest prevalence of severe periodontitis, with a significant correlation between increased probing pocket depth and reduced ejection fraction. Candida species abundance was associated with lower ejection fraction (p≤0.0Y) and advanced periodontitis (p≤0.0X). Elevated NT-proBNP levels (1121.00–7611.00 pg/mL) correlated with Streptococcus mitis prevalence, while C-reactive protein levels (up to 2.35 mg/dL) were highest in patients with Klebsiella pneumoniae.
Conclusion. The study highlights a strong association between periodontal disease, microbial dysbiosis, and CHF. Findings suggest that oral microbial imbalances, particularly involving Candida, Streptococcus mitis, and Klebsiella pneumoniae, contribute to systemic inflammation and cardiovascular complications.
Ключевые слова
dental health surveys, gingiva pathology, heart failure, inflammation, periodontal index
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Features Of Risk Factors For The Development Of Atherosclerosis-Associated Cardiovascular Diseases In The Kazakhstani Population. Ethnonational Aspect (Выпуск № 3, 2025)
Makhabbat Bekbossynova, Tatyana Ivanova-Razumova, Aliya Sailybayeva, Sadyk Khamitov, Kamila Akzholova2025-09-3043–55Аннотация
Background. Atherosclerosis-associated cardiovascular diseases exhibit significant ethnic and regional variability in risk factors. Kazakhstan’s high cardiovascular disease mortality rates necessitate population-specific profiling, particularly given urban-rural disparities and lifestyle differences unique to Central Asia.
Methods. This cross-sectional study (2023–2024) analyzed 368 Kazakhstani adults stratified by European Atherosclerosis Society risk tiers: low (n=67), high (n=127), and very high risk (very high-risk group, n=174). Assessments included lipid profiles (low density lipoprotein, high density lipoprotein, and apolipoprotein B to apolipoprotein A ratio), lifestyle factors (smoking, diet, physical activity), and residence (urban/rural). Statistical analyses employed multiclass logistic regression (MNLogit) with FDR-adjusted p-values.
Results. Age (OR=8.01, 95% CI:4.40–14.58, p<0.001), male sex (OR=3.27, CI:1.82–5.88), and smoking (OR=7.19, CI:1.52–34.15) were strongly associated with very high-risk group. Rural residents faced 2.6-fold higher very high-risk group odds (CI:1.52–5.68, p=0.002) versus urban counterparts. Protective effects emerged for physical activity (OR=0.03, CI:0.004–0.32) and female sex (High-Density Lipoprotein: +8.1 mg/dL vs. males, p<0.001). No alcohol association was observed (p=0.836).
Conclusion. A thorough study of the gender aspect of the development of atherosclerotic pathology is required. Physical activity has a strong protective effect. It is interesting that, according to the comparative analysis of binary variables, rural residents have a higher risk of developing atherosclerosis.
Ключевые слова
atherosclerosis, cardiovascular risk factors, Kazakhstan, urban-rural disparities, lipid metabolism, preventive cardiology
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Social efficiency of introduction of atherosclerosis screening program in Kazakhstan. Systematic review (Выпуск № 1, 2025)
M. Bekbossynova, S. Duisekova, A. Zeinoldina, G. Daniyarova, K. Akzholova2025-03-3172–87Аннотация
Background. Atherosclerosis, a major cause of cardiovascular disease, has a significant impact on morbidity and mortality in Kazakhstan. The increasing burden of this disease, combined with a high prevalence of dyslipidemia, underscores the importance of effective screening to reduce associated health risks. The aim of this study is to evaluate the social efficiency of implementing a nationwide atherosclerosis screening program in Kazakhstan and to assess its potential to improve public health outcomes and reduce mortality from cardiovascular disease.
Methods. A literature review was conducted, and global screening approaches and protocols for atherosclerosis and cardiovascular disease were analyzed for their applicability in the local context.
Results. Results suggest that targeted and cascade screening programs, particularly those focused on high-risk individuals and familial hypercholesterolemia, are effective in reducing disease incidence and mortality. Implementation of similar protocols in Kazakhstan could improve early detection, allowing for preventive interventions and treatment. The study concludes that a structured, government-sponsored screening program would not only save lives but also provide substantial economic benefits by reducing long-term health care costs associated with cardiovascular complications.
Conclusion. Screening is the convenient and economically efficient way to prevent atherosclerosis, and its effectiveness is demonstrated by worldwide practice and the history of early disease prevention. However, the effectiveness and social value of screening need to be demonstrated before it can be incorporated into medical practice. If established as a regular practice, widespread population screening could dramatically reduce cardiovascular disease, the leading cause of death worldwide.
Ключевые слова
atherosclerosis, dyslipidemia, cardiovascular diseases, lipid profile, screening
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Correlation between apolipoprotein b/a1 and the risk of metabolic-related fatty liver disease depending on the lipid profile (Выпуск № 1, 2025)
M. Bekbossynova, G. Myrzakhmetova, S. Seitkasym, A. Sailybaeva, S. Khamitov, G. Daniyarova, K. Akzholova2025-03-3129–36Аннотация
Background. The aim of this study was to investigate the relationship between the Apolipoprotein B/Apolipoprotein A1 ratio and the risk of metabolically associated fatty liver disease, considering lipid profile variations and determine whether the Apolipoprotein B/Apolipoprotein A1 ratio can serve as an independent predictor of metabolically associated fatty liver disease and its associated cardiovascular risks.
Methods. A total of 377 patients diagnosed with cardiovascular disease and coexisting metabolically associated fatty liver disease were stratified into high-risk and very high-risk groups based on established clinical and imaging criteria. Lipid profiles, Apolipoprotein B, and Apolipoprotein A1 levels were measured, and their associations with cardiovascular and metabolic parameters were analyzed using correlation and regression models.
Results. The findings reveal a strong positive correlation between Apolipoprotein B levels and atherogenic lipid markers such as low-density lipoproteins cholesterol and total cholesterol, as well as a moderate correlation with triglycerides. In contrast, Apolipoprotein A1 demonstrated a strong positive association with high-density lipoproteins cholesterol and an inverse correlation with metabolic indicators such as Hemoglobin A1c and glucose, suggesting a potential protective role. The Apolipoprotein B/Apolipoprotein A1 ratio emerged as a more accurate predictor of cardiovascular and metabolic risk than traditional lipid ratios. Furthermore, the Apolipoprotein B/Apolipoprotein A1 ratio was significantly associated with the presence and severity of metabolically associated fatty liver disease, reinforcing its potential utility as a biomarker for metabolic liver disease.
Conclusion. This study highlights the clinical relevance of incorporating apolipoprotein measurements into the routine assessment of individuals at risk for metabolic and cardiovascular disease.
Ключевые слова
Apolipoprotein B, Apolipoprotein A1, metabolic-associated fatty liver disease, cardiovascular disease, lipid metabolism, dyslipidemia, risk assessment
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Myocardial dysfunction in polytrauma (Выпуск № 3, 2024)
M.S. Bekbossynova, A.N. Batpen, M.A. Mukarov, Z.M. Shaktybek, M.M. Sugralimova, B.M. Mamasaliev, M.K. Lukbanov, P. S. Kanabekova, A.I. Kozhakhmetova2024-09-3054–64Аннотация
Trauma remains one of the leading causes of mortality worldwide, particularly among the young population. A significant number of people die within the first 48 hours due to acute cardiovascular pathology. Cardiac injury is a significant predictor of adverse outcomes following multiple trauma, associated with poor prognosis and prolonged hospitalization. Systemic elevation of cardiac troponin levels is linked to survival, the severity of trauma, and catecholamine consumption in patients after multiple trauma. Clinical signs of the so-called "commotio cordis" include arrhythmias, such as ventricular fibrillation and sudden cardiac arrest, as well as wall motion abnormalities. In trauma patients with inadequate hypotension and a lack of adequate response to fluid therapy, the possibility of cardiac injury should be considered. Therefore, a combination of electrocardiography, echocardiography, and the systemic determination of cardiomyocyte injury markers, such as troponin, appears to be an appropriate diagnostic method for identifying cardiac dysfunction after trauma. However, the mechanisms of post-traumatic cardiac dysfunction continue to be actively studied. The aim of this review is to discuss cardiac injury following trauma, focusing on the mechanisms of post-traumatic cardiac dysfunction related to inflammation and complement activation. The review illustrates the causal relationship between cardiac dysfunction and blunt chest trauma, multiple trauma, and hemorrhagic shock.
Ключевые слова
trauma, myocardial dysfunction, immunology
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Особенности течения неалкогольной жировой болезни печени при сахарном диабете 2 типа и нарушении толерантности к глюкозе (Выпуск № 2, 2024)
М. С. Бекбосынова, Г. Ш. Мырзахметова, Ш. К. Сейткасым, А.И. Сайлыбаева, С.Р. Хамитов, Ж. О. Оралбекова, Г. Д. Даниярова2024-06-2839–49Аннотация
Фон. Неалкогольная жировая болезнь печени и сахарный диабет 2 типа или нарушение толерантности к глюкозе являются распространёнными заболеваниями с высоким риском развития сердечно-сосудистых заболеваний, основной причиной инвалидности и смерти. Наша цель - разработать новые методы скрининга, профилактики и лечения сердечно-сосудистых заболеваний у пациентов с вышеуказанными заболеваниями. Методы и методология. Данное исследование является одно-центровым, открытым, неконтролируемым, диагностическим. В период с 2023 по февраль 2024 года в Кардиологическом центре «Университетский медицинский центр» Корпоративного фонда отобрано 216 пациентов с сердечно-сосудистыми заболеваниями и сопутствующей неалкогольной жировой болезнью печени, сахарным диабетом 2 типа и нарушением толерантности к глюкозе.
Результаты. У всех обследованных больных с сердечно-сосудистыми заболеваниями и сопутствующей неалкогольной жировой болезнью печени выявлено повышение активности печеночных ферментов. Показатели липидного профиля крови достоверно превышали оптимальные уровни для пациентов с сердечно-сосудистыми заболеваниями. Также отмечено достоверное увеличение ферментов печени, С-реактивного белка, триглицеридов и малого липопротеина у пациентов с сердечно-сосудистыми заболеваниями и неалкогольной жировой болезнью печени в сочетании с сахарным диабетом 2 типа и нарушением толерантности к глюкозе. Выводы. Анализ активности ферментов печени, С-реактивного белка, глюкозы и липидограммы показал достоверное увеличение этих показателей у пациентов с сердечно-сосудистыми заболеваниями и неалкогольной жировой болезнью печени, особенно при наличии сахарного диабета 2 типа и нарушения толерантности к глюкозе. У всех обследованных больных наблюдалось повышение активности ферментов печени и уровня липидов, что свидетельствует о влиянии этих заболеваний на печень и обмен веществ.
Ключевые слова
Неалкогольная жировая болезнь печени, Сахарный диабет 2 тип, толерантность к глюкозе, Сердечно-сосудистые заболевания, Метаболический синдром
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Связь между уровнем общего билирубина и частотой развития атеросклероза: систематический обзор и мета-анализ (Выпуск № 2, 2024)
М. С. Бекбосынова, Т. В. Иванова-Разумова, А. Ержан, Г. Д. Даниярова, С. Р. Хамитов2024-06-2832–38Аннотация
Өзектілігі. Билирубин-эритроциттердің ыдырауының жанама өнімі. Билирубин деңгейі жүрек-қан тамырлары қаупін бағалау үшін биомаркер бола алады. Бұл зерттеуде біз сарысулық билирубин деңгейінің атеросклероздың прогрессиясымен байланысын зерттеген соңғы 5 жылда жарияланған ең соңғы қолжазбаларды зерттеп, жалпы билирубин деңгейінің аурудың дамуын қаншалықты төмен болжай алатынын анықтаймыз.
Әдістері. PubMed іздеу жүйесінің көмегімен "билирубин" және "атеросклероз"кілттік сөздері бар барлық мақалалар табылды. 2019-2023 жылдар кезеңінде, соңғы 5 жылда барлығы 67 іздеу нәтижелері пайда болды. Мета-талдау үшін жалпы билирубин концентрациясы мен атеросклероздың дамуы арасындағы байланысты зерттейтін 6 популяциялық зерттеу қолданылды.
Нәтижелер. қандағы жалпы билирубин деңгейінің жоғарылауы атеросклероздың даму ықтималдығын төмендетеді, яғни жалпы билирубин деңгейі мен артериялық бляшкалардың пайда болуы немесе стеноз арасында кері байланыс бар. Біріктірілген коэффициент 0.86 (95% СИ 0.83–0.9) болды, бұл ммоль/л үшін билирубин деңгейінің әрбір жоғарылауымен атеросклероздың даму ықтималдығы 14% төмендейтінін көрсетеді. Жалпы, сарысудағы жалпы билирубиннің жоғары деңгейі атеросклероздың даму қаупінің айтарлықтай төмендеуімен байланысты болды.
Қорытынды. Мета-талдау жалпы билирубиннің төмен деңгейі мен атеросклероздың даму қаупі арасындағы айтарлықтай кері байланысты көрсетеді, бұл билирубиннің жоғары деңгейі аурудың дамуынан қорғай алады деп болжайды.
Ключевые слова
Уровень Общего Билирубина, Атеросклероз, Мета-анализ, Сердечно-Сосудистая Система
