1. Structural Changes In The Thyroid And Adrenal Glands In Acute Hypoxia
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Abstract
The article provides information about the research work carried out to study the patho- and morpho-genetic features of morphofunctional changes occurring in the tissue structures of the thyroid and adrenal glands under the influence of barocamera hypoxia. The object of the study were the thyroid and adrenal glands of adult male white rats with a mass of 180-200 grams. In the course of the study, anatomic, histological and morphometric examination methods were used. During the morphological study of the thyroid and adrenal glands parenchyma and stroma of the glands in all animals under the infuence of acute hypoxia, diffuse edema, acute dilatation of the vessels in the microcirculatory bed, fragmentation of the walls, violation of the completeness of the endothelial layer, absorption of blood plasma into the vascular wall were observed. These dystrophic changes are more pro-nounced in the adrenal gland than in the thyroid gland. This is explained by the fact that the adrenal gland is more sensitive to stress factors and cells are more damaged, and the thyroid gland is more early to hypoxia.
Keywords
thyroid gland, adrenal glands, acute hypoxia
References
- Zarechnova N. N., Slynko E. N. Influence of mountain hypoxia on endocrine system organs at insufficiency of adrenal and pancreatic hormones / / Bulletin of new medical technologies, electronic journal, 2018, № 4, p. 3-10
- Zerkalova Y. F. Morphological and functional changes of some endocrine glands during hypoxia of different gen-esis // Avtoref.cand.dis..., Ulyanovsk, 2004, 23 p
- Kalyuzhnaya L. I. Endocrine mechanisms of adapta-tion to the high altitude [Text]: in the book: Hypoxia. Adaptation, pathogenesis, clinic // Under the editor-ship of J. L. Shevchenko / Kalyuzhnaya, L. I., Tararak T. I., Kalyuzhny I. T.– SPb: LLC “ELBI-SPb”, 2000, 235-265
- Sadykova G. S., Dzhunusova G. S. Functional fea-tures of endocrine systems in the inhabitants of the highlands / / International journal of applied and fun-damental research, 2016, № 4-5, pp. 943-947
- Mukhametov A. I. Morphofunctional characteristic of adrenal glands of rabbits in the conditions of stress and its correction // Author’s abstract. Cand. Dis..., Orenburg, 2015, 24 p
- Vasilyeva O.A. Morphology of the thyroid gland of adult residents of Smolensk //Autoref.Cand. Dis..., 22 p., St. Petersburg, 2011
- Tupikina E. B. et al. Morphofunctional characteris-tics of cellular and tissue components of the thyroid gland in its pathology / / Archive-pathology. 2000. - No. 5. - p.24-29
- Stadnik N.A., Botasheva V.S. Morphology of thyroid gland in experimental thyrotoxicosis / / Kuban scien-tific medical bulletin No. 3 (145) 2014, pp. 102-108
- Khmelnitsky O. K. Cytological and histological diag-nosis of thyroid diseases. SPb.: SOTIS, 2002. - 288с
- Burrows N, Resch J, Cowen RL, von Wasielewski R, Hoang-Vu C, West CM, et al. Expression of hypoxia-inducible factor 1α in thyroid carcinomas. Endocrine-related Cancer, 2010; 17(1):61-72
- Jówziak P, Ciesielski P, Zaczek A, Lipinska A, Po-morski L, Wieczorek M, et al. Expression of hypoxia inducible factor 1α and 2α and its association with vitamin C level in thyroid lesions. Journal of Biomedi-cal Science 2017; 24(1):83
- Mohammed Assi1, Samia Elewi1, Ahmed Al-Imam, Basem Ahmed The significance of hypoxia as a molecular and cellular event in patients with toxic and non-toxic goitre: A statistical inference based on cross-sectional analytic of Iraqi patients //Asian Journal of Medical Sciences, 2018, V. 9, Iss. 5, p.44-49
- Peeri M, Kohanpour MA, Sanavi S, Pazukian M, Ja-farabadi MA, Mirsepasi M. Effects of submaximal aerobic exercise on thyroid hormones in hypoxic conditions in trained young men. Thyroid Res. Pract. 2012; (9):88-92
- Warner S. Simonides, Michelle A. Mulcahey, Everal-do M. Redout at all. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats//J Clin Invest. 2008 Mar 3; 118(3): 975–983
