Moldir Seitbek

https://orcid.org/0000-0002-4094-7771

Articles found: 1

  • Comparative Analysis Of Bisoprolol Efficacy In Patients With Normal And Altered Cardiac Anatomy In The Postoperative Period After Catheter Ablation Of Atrial Fibrillation (Issue № 3, 2025)

    Adil Baimbetov, Karlygash Kissikova, Madi Tokhtarov, Omirzhan Rysbayev, Ilinara Akhmetzhan, Moldir Seitbek, Alexander Sapunov, Rzaev Farkhad
    2025-09-30
    73–83
    Abstract

    Background. The aim of this study was to evaluate the effectiveness of the β-adrenergic blocker bisoprolol in maintaining sinus rhythm in patients with atrial fibrillation following catheter ablation of the pulmonary vein ostia, considering the anatomical condition of the left atrium.

    Material and methods. A total of 50 patients were enrolled and divided into two groups: those with normal left atrial anatomy (n = 25) and those with pathologically altered anatomy (n = 25). All patients received bisoprolol at a dose of 10 mg/day for 12 months post-ablation.

    Results. Within the first 6 months of follow-up, no atrial fibrillation recurrences were observed in the group with normal left atrium anatomy (100%), whereas 92% of patients in the altered anatomy group experienced recurrences. In the second half of the follow-up period (months 6–12), differences between the groups were no longer statistically significant. Statistical analysis confirmed a highly significant difference in recurrence rates during the early postoperative period (p < 0.001) and no significant difference in the late period (p > 0.3).

    Conclusion. The effectiveness of bisoprolol in maintaining sinus rhythm is highly dependent on the anatomical condition of the left atrium in the early period following ablation. The results highlight the importance of individualizing antiarrhythmic therapy based on morphofunctional characteristics.

    Keywords

    atrial fibrillation, catheter ablation, bisoprolol, β-adrenergic blockers, left atrial anatomy