K. Yakupova

https://orcid.org/0000-0002-2726-7296

Articles found: 3

  • Comparative Analysis Of Bisoprolol Efficacy In Patients With Normal And Altered Cardiac Anatomy In The Postoperative Period After Catheter Ablation Of Atrial Fibrillation (Issue № 3, 2025)

    Adil Baimbetov, Karlygash Kissikova, Madi Tokhtarov, Omirzhan Rysbayev, Ilinara Akhmetzhan, Moldir Seitbek, Alexander Sapunov, Rzaev Farkhad
    2025-09-30
    73–83
    Abstract

    Background. The aim of this study was to evaluate the effectiveness of the β-adrenergic blocker bisoprolol in maintaining sinus rhythm in patients with atrial fibrillation following catheter ablation of the pulmonary vein ostia, considering the anatomical condition of the left atrium.

    Material and methods. A total of 50 patients were enrolled and divided into two groups: those with normal left atrial anatomy (n = 25) and those with pathologically altered anatomy (n = 25). All patients received bisoprolol at a dose of 10 mg/day for 12 months post-ablation.

    Results. Within the first 6 months of follow-up, no atrial fibrillation recurrences were observed in the group with normal left atrium anatomy (100%), whereas 92% of patients in the altered anatomy group experienced recurrences. In the second half of the follow-up period (months 6–12), differences between the groups were no longer statistically significant. Statistical analysis confirmed a highly significant difference in recurrence rates during the early postoperative period (p < 0.001) and no significant difference in the late period (p > 0.3).

    Conclusion. The effectiveness of bisoprolol in maintaining sinus rhythm is highly dependent on the anatomical condition of the left atrium in the early period following ablation. The results highlight the importance of individualizing antiarrhythmic therapy based on morphofunctional characteristics.

    Keywords

    atrial fibrillation, catheter ablation, bisoprolol, β-adrenergic blockers, left atrial anatomy

  • The role of interleukins in the pathogenesis of atrial fibrillation: literature review (Issue № 3, 2024)

    A.T. Aubakirova, A.K. Baimbetov, A.V. Sapunov, I.A. Yakupova, K.A. Bizhanov, L.E. Rizabekova, N.J. Bigeldiev
    2024-09-30
    90–97
    Abstract

    Relevance. Atrial fibrillation (AF) is the most common arrhythmia, which negatively affects the quality of life and significantly increases the risk of thrombosis, strokes and cardiovascular diseases. The pathogenesis of AF is a complex and multifactorial process in which inflammatory and immune mechanisms play an important role. In recent years, special attention has been paid to interleukins, cytokines that regulate the immune response, which may influence the development and maintenance of AF. The study of the role of interleukins in the pathogenesis of AF may provide new perspectives for understanding the mechanisms of the occurrence of this arrhythmia and the development of effective methods of its prevention and treatment. The study aimed to evaluate the influence of interleukins on the pathogenesis of atrial fibrillation and to identify possible mechanisms of their action.

    Methods. data concerning the role of interleukins in the pathogenesis of atrial fibrillation were analyzed during the analysis of scientific publications. A systematization of existing studies, including both clinical and experimental data that show a link between the levels of interleukins (IL-1, IL-6, IL-17 and others) and the development of AF was performed. Search methods included analyzing publications in PubMed, Scopus and Web of Science databases over the last ten years and using keywords related to interleukins and AF.

    Results. The results indicate that interleukins such as IL-1, IL-6, IL-17 and IL-18 play a significant role in the inflammatory processes associated with AF. Elevated levels of IL-6 correlate with worsening cardiac function and an increased likelihood of developing AF. In addition, IL-1 may contribute to myocardial remodeling, which is a key factor in the pathogenesis of AF. Other interleukins, such as IL-17, are also associated with inflammatory processes affecting cardiac electrical stability. Accumulating evidence suggests that interleukins can affect cellular hypertrophy and fibrosis, leading to changes in cardiac structure and contributing to the development of AF. The inclusion of interleukins in risk prediction models for the development of AF may improve preventive strategies and individualize the treatment of patients at risk.

    Conclusion. the analysis shows that interleukins play a key role in the pathogenesis of atrial fibrillation by participating in inflammatory processes and abnormalities in cardiac electrophysiology. Further studies are needed to clarify their mechanisms of action and to develop new therapeutic strategies aimed at reducing interleukin levels and improving the prognosis of patients with AF.

    Keywords

    atrial fibrillation, interleukins, inflammation, pathogenesis, cardiovascular diseases, IL-1, IL-6, IL-17

  • The influence of pulmonary vein anatomy on outcomes after ablation of paroxysmal atrial fibrillation (Issue № 3, 2024)

    A. Baimbetov, A. Jukenova, A. Ualiyeva, K. Bizhanov, A. Sapunov, N. Bigeldiyev, K. Yakupova, N. Okhabekov, Zh. Meirambay
    2024-09-30
    82–89
    Abstract

    Background. Pulmonary vein isolation is the cornerstone of catheter-based treatment for atrial fibrillation. Cryoballoon ablation offers an effective and reproducible method for pulmonary vein isolation, yet recurrence of arrhythmias remains a challenge. Despite advances in catheter technologies, the role of altered pulmonary vein anatomy as a factor for atrial fibrillation recurrence is poorly studied. Materials and

    Methods. This prospective study included 465 patients with paroxysmal atrial fibrillation who underwent cryoballoon ablation. Pulmonary vein and left atrial anatomy were evaluated using multislice computed tomography. Patients were followed for 24–48 months to assess atrial fibrillation recurrence and anatomical risk factors. Cox proportional hazard modeling and Kaplan-Meier analysis were used to evaluate predictors of arrhythmia recurrence.

    Results. Complete Pulmonary vein isolation was achieved in all patients. During follow-up, 38% of patients experienced atrial fibrillation recurrence. Patients with altered pulmonary vein anatomy, particularly a left common pulmonary vein and additional pulmonary veins, showed a higher rate of recurrence. Cox regression analysis identified left atrial volume index >50 mL/m² and pathological pulmonary vein anatomy as independent risk factors for atrial fibrillation recurrence.

    Conclusion. Altered pulmonary vein anatomy is a significant risk factor for atrial fibrillation recurrence following cryoballoon ablation. Comprehensive imaging of the left atrial and pulmonary vein using multislice computed tomography can improve patient selection, reducing the recurrence risk and improving long-term outcomes.

    Keywords

    Atrial fibrillation, cryoballoon ablation, pulmonary vein anatomy, recurrence, pulmonary vein isolation, multislice computed tomography