10. Role of extracorporeal liver support methods in the treatment of acute liver failure: a clinical case and a literature review

Abstract

The liver is an essential organ in the human body, responsible for a multitude of critical tasks. Diseases affecting the liver can be incredibly serious, often endangering life. At present, liver transplantation stands as the only demonstrated successful remedy for these acute ailments. Early investigations explored non-biological treatments, employing conventional deto[Lʖcation techniques such DV ʖltration and dialysis The absence RI liver cells LQ these methods limited patient survival and failed WR sufʖciently provide essential liver speciʖF functions This prompted increasing interest LQ GHYHORSing biological therapy-based extracorporeal liver support systems, intended as a temporary measure leading to liver transplantation or as a supportive approach for a failing liver $ bioartiʖcial liver support system involves DQ H[tracorporeal device circulating plasma over living and actively functioning hepatocytes within a bioreactor. This system is designed to assist the diseased liver until it either recovers on its own or until a suitable transplant organ becomes available. This review presents a concise summary of the effectiveness of currently available liver support systems. Furthermore, it explores the progression of advanced liver support systems, assessing enhancements to critical elements like the cell source, along with culture and circulation conditions, for the maintenance RI crucial liver speciʖF functionalities '2, %6. ,, Kuandykov T.