12. The role of interleukins in the pathogenesis of atrial fibrillation: literature review

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https://doi.org/10.35805/BSK2024III011

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Abstract

Relevance. Atrial fibrillation (AF) is the most common arrhythmia, which negatively affects the quality of life and significantly increases the risk of thrombosis, strokes and cardiovascular diseases. The pathogenesis of AF is a complex and multifactorial process in which inflammatory and immune mechanisms play an important role. In recent years, special attention has been paid to interleukins, cytokines that regulate the immune response, which may influence the development and maintenance of AF. The study of the role of interleukins in the pathogenesis of AF may provide new perspectives for understanding the mechanisms of the occurrence of this arrhythmia and the development of effective methods of its prevention and treatment. The study aimed to evaluate the influence of interleukins on the pathogenesis of atrial fibrillation and to identify possible mechanisms of their action.

Methods. data concerning the role of interleukins in the pathogenesis of atrial fibrillation were analyzed during the analysis of scientific publications. A systematization of existing studies, including both clinical and experimental data that show a link between the levels of interleukins (IL-1, IL-6, IL-17 and others) and the development of AF was performed. Search methods included analyzing publications in PubMed, Scopus and Web of Science databases over the last ten years and using keywords related to interleukins and AF.

Results. The results indicate that interleukins such as IL-1, IL-6, IL-17 and IL-18 play a significant role in the inflammatory processes associated with AF. Elevated levels of IL-6 correlate with worsening cardiac function and an increased likelihood of developing AF. In addition, IL-1 may contribute to myocardial remodeling, which is a key factor in the pathogenesis of AF. Other interleukins, such as IL-17, are also associated with inflammatory processes affecting cardiac electrical stability. Accumulating evidence suggests that interleukins can affect cellular hypertrophy and fibrosis, leading to changes in cardiac structure and contributing to the development of AF. The inclusion of interleukins in risk prediction models for the development of AF may improve preventive strategies and individualize the treatment of patients at risk.

Conclusion. the analysis shows that interleukins play a key role in the pathogenesis of atrial fibrillation by participating in inflammatory processes and abnormalities in cardiac electrophysiology. Further studies are needed to clarify their mechanisms of action and to develop new therapeutic strategies aimed at reducing interleukin levels and improving the prognosis of patients with AF.

Keywords

atrial fibrillation, interleukins, inflammation, pathogenesis, cardiovascular diseases, IL-1, IL-6, IL-17

References

  1. Mohammad Erfan Lotfi, Parmida Sadat Pezeshki, Nima Rezaei. The role of interleukins in pathogen-esis and prognosis of atrial fibril-lation. // Expert Review of Clinical Immunology. - 2023(6).- Vol.19. DOI:10.1080/1744666X.2023.2196013
  2. World Health Organization. (2020, December 9). The top 10 causes of death. Retrieved from: https://www. who.int/news-room/fact-sheets/de-tail/the-top-10-causes-of-death
  3. Staerk L, Sherer JA, Ko D, Benja-min EJ, Helm RH. Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes. // Circulation Re-search. – 2017. -28;120(9). – P.1501-1517. DOI:10.1161/CIRCRESA-HA.117.309732
  4. Karim Benali, Valentin Barré, Ra-phaël P. Martins et al. Recurrences of Atrial Fibrillation Despite Dura-ble Pulmonary Vein Isolation: The PARTY-PVI Study. AHA //Circulation: Arrhythmia and Electrophysiolo-gy. -2023. -N
  5. Jelena Kornej, Christin S. Börschel, Emelia J. Benjamin, Renate B. Sch-nabel. Epidemiology of Atrial Fibrilla-tion in the 21st Century. //Circulation Research. 2020. -127. – P.4–20. DOI:10.1161/CIRCRESAHA.120.316340
  6. Abubakar M, Rasool H, Javed I, et al. Comparative Roles of IL-1, IL-6, IL-10, IL-17, IL-18, 1L-22, IL-33, and IL-37 in Various Cardiovascular Diseases With Potential Insights for Targeted Immunotherapy // Cureus. – 2023. - 15(7): e42494. DOI:10.7759/cureus.42494
  7. Rafaqat, S., Rafaqat, S., &Rafaqat, S. ). Major Interleukins: Role in the Pathogenesis of Atrial Fibrillation. // MIAS. - 35(1). DOI:10.24207/jca.v35i1.3470
  8. Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, et al. IL-1β plays an important role in pressure overload-induced atrial fibrillation in mice. //Biological and Pharmaceutical Bulletin. – 2019. -N42(4). – P.543-6. DOI:10.1248/bpb.b18-00363
  9. Feng Y, Ye D, Wang Z, et al.: The role of interleukin-6 family members in cardiovascular diseases. //Fron-tiers in Cardiovascular Medicine. – 2022. – 9. - P.818890. DOI:10.3389/fcvm.2022.818890
  10. Yue, H., Gu, J., Zhao, X., Liang, W., Wu, Z. . Role of the interleukin-17 pathway in the pathogenesis of atrial fibrillation associated with inflam-mation. //Archives of Medical Sci-ence. 2021. - 17(1), 262-265. DOI:10.5114/aoms/130392
  11. Hu, Y.-F., Chen, Y.-J., Lin, Y.-J., and Chen, S.-A. (2015). Inflammation and the Pathogenesis of Atrial Fibrilla-tion. Nat. Rev. Cardiol. 12 (4), 230– 243. doi:10.1038/nrcardio.2015.2
  12. Dobrev, D., Aguilar, M., Heijman, J., Guichard, J.-B., and Nattel, S. (2019). Postoperative Atrial Fibrillation: Mechanisms, Manifestations and Management. Nat. Rev. Cardiol. 16 (7), 417–436. doi:10.1038/s41569-019-0166-5
  13. Matsushita, N., Ishida, N., Ibi, M., Saito, M., Takahashi, M., Tanigu-chi, S., et al. (2019). IL-1β Plays an Important Role in Pressure Over-load-Induced Atrial Fibrillation in Mice. Biol. Pharm. Bull. 42 (4), 543– 546. doi:10.1248/bpb.b18-00363
  14. Cabaro S., Conte М., Moschetta D., Petraglia L., Valerio V/, Romano S., Francesco Di Tolla M., Campana P., Comentale G., Pilato E., D'Esposito V., Di Mauro A., Cantile M., Poggio P., Leosco D., Formisano P. Epicardial Adipose Tissue-Derived IL-1β Trig-gers Postoperative Atrial Fibrilla-tion // Front Cell Dev Biol.
  15. Zegeye MM, Lindkvist M, Fälker K, Kumawat AK, Paramel G, Grenegård M, et al., Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in hu-man vascular endothelial cells Cell Commun Signal. (2018) 16:55. doi:10.1186/s12964-018-0268-4
  16. Amdur RL, Mukherjee M, Go A, Bar-rows IR, Ramezani A, Shoji J, et al. Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study. PloS ONE. (2016) 11:e0148189. doi:10.1371/journal.pone.0148189
  17. Xie J, Zhu S, Dai Q, Lu J, Chen J, Li G, et al. Oncostatin M was as-sociated with thrombosis in pa-tients with atrial fibrillation. Medi-cine. (2017) 96:e6806. doi:10.1097/MD.0000000000006806
  18. Grymonprez M, Vakaet V., Kavousi M, Stricker B.H., Ikram M. A., Hee-ringa J.J., Franco H.O, Brusselle G.G., Lahousse L. The role of inter-leukin 6 on incident atrial fibrilla-tion in COPD patients//European Respiratory Journal. -2018. - 52: PA3612; DOI:10.1183/13993003.con-gress-2018.PA3612

Published

2024-09-30

Issue

No. 3 (2024)

Section

Статьи