9. The effect of overweight and obesity on dyslipidemia: cross-sectional study in heart center

Authors

  • M. Bekbossynova «University Medical Center» Corporate Fund, Astana, Kazakhstan
  • A. Rysbekova «University Medical Center» Corporate Fund, Astana, Kazakhstan
  • S. Andosova «University Medical Center» Corporate Fund, Astana, Kazakhstan
  • A. Sailybaeva «University Medical Center» Corporate Fund, Astana, Kazakhstan
  • G. Daniyarova «University Medical Center» Corporate Fund, Astana, Kazakhstan

DOI:

https://doi.org/10.35805/BSK2024III009

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Abstract

Background. Obesity has turned into a worldwide epidemic with increasing prevalence that is associated with excess mortality and morbidity. Obesity is a risk factor for many diseases including cardiovascular disease, the leading cause of death worldwide. Aim of the study was conducted to evaluate the association of obesity with dyslipidemia and hypertension among patients with low, medium and high risk of developing cardiovascular diseases

Materials and methods. Cross-sectional study was conducted at the tertiary hospital in Astana, Kazakhstan. In total 216 participants included in this study.

Results. Student’s t test was performed to elicit association between body mass index and lipid panel analysis such as cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein, where all p values found to be <0.0001. Consequently, there is a statistically significant association, and increased body mass indexis linked with higher lipids in the body.Obesity increases risk of atherosclerosis 2.81 times in comparison those who have a normal body mass index. Obesity increases risk of coronary angioplasty with stenting 1.91 times in comparison those who did not undergo stenting procedure.

Conclusion. Atherogenic dyslipidemia is extremely common in obesity, both in the presence and in the absence of severe insulin resistance, and is probably the main factor in the increased risk of cardiovascular diseases in these people

Keywords

Obesity, Dyslipidemia, Cardiovascular risk factors, Сardiometabolic diseases

References

  1. Afshin A, Murray CJL. Uncertainties in the GBD 2017 estimates on diet and health - Authors' reply. Lancet. Nov 16 2019;394(10211):1802-1803. doi:10.1016/S0140-6736(19)32629-7
  2. Duncan BB, Cousin E, Naghavi M, et al. The burden of diabetes and hyper-glycemia in Brazil: a global burden of disease study
  3. Tsao CW, Aday AW, Almarzooq ZI, et al. Heart Disease and Stroke Statis-tics-2022 Update: A Report From the American Heart Association. Circu-lation. Feb 22 2022;145(8):e153-e639. doi:10.1161/CIR.0000000000001052
  4. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obe-sity in children and adults during 1980-2013: a systematic analy-sis for the Global Burden of Dis-ease Study
  5. Kulimbet M, Davletov K, Saliev T, et al. Assessment of hypercholes-
  6. Richard AJ, White U, Elks CM, Ste-phens JM. Adipose Tissue: Physiol-ogy to Metabolic Dysfunction. In: Fe-ingold KR, Anawalt B, Blackman MR, et al, eds. Endotext. 2000
  7. Youssef A, Clark JR, Marcovina SM, Boffa MB, Koschinsky ML. Apo(a) and ApoB Interact Noncovalent-ly Within Hepatocytes: Implications for Regulation of Lp(a) Levels by Modulation of ApoB Secretion. Ar-terioscler Thromb Vasc Biol. Mar 2022;42(3):289-304. doi:10.1161/AT-VBAHA.121.317335
  8. Hillmeister P, Li K, Dai M, et al. Li-poprotein(a) as a risk factor for ath-erosclerotic cardiovascular disease in patients in non-metropolitan ar-eas of Brandenburg, Germany. Front Cardiovasc Med. 2024;11:1302152. doi:10.3389/fcvm.2024.1302152
  9. Afshin A, Lo J, Murray CJL. Dietary risk versus physical inactivity: a forced comparison with policy impli-cations? - Authors' reply. Lancet. May 8 2021;397(10286):1710. doi:10.1016/S0140-6736(21)00781-9
  10. Wang DD, Li Y, Afshin A, et al. Glob-al Improvement in Dietary Quality Could Lead to Substantial Reduction in Premature Death. J Nutr. Jun 1 2019;149(6):1065-1074. doi:10.1093/jn/nxz010
  11. Shangguan S, Afshin A, Shulkin M, et al. A Meta-Analysis of Food Labeling Effects on Consumer Diet Behav-iors and Industry Practices. Am J Prev Med. Feb 2019;56(2):300-314. doi:10.1016/j.amepre.2018.09.024
  12. Richard AJ, Huckfeldt RM, Reichel E, Liang MC. Variants of Uncertain Significance: Twins With Identi-cal Pathogenic Gene Mutations in Retinitis Punctata Albescens. Ophthalmic Surg Lasers Imaging Retina. Aug 2021;52(8):450-453. doi:10.3928/23258160-20210727-08
  13. Bovet P, Chiolero A, Gedeon J. Health Effects of Overweight and Obesity in 195 Countries. N Engl J Med. Oct 12 2017;377(15):1495-6. doi:10.1056/NEJMc1710026
  14. Lee SY, Chang HJ, Sung J, et al. The impact of obesity on subclinical coro-nary atherosclerosis according to the risk of cardiovascular disease. Obesi-ty (Silver Spring). Jul 2014;22(7):1762-8. doi:10.1002/oby.20760
  15. Gill D, Zuber V, Dawson J, et al. Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis. Int J Obes (Lond). Jul 2021;45(7):1428-1438. doi:10.1038/s41366-021-00807-4
  16. Henning RJ. Obesity and obesity-in-duced inflammatory disease contrib-ute to atherosclerosis: a review of the pathophysiology and treatment of obesity. Am J Cardiovasc Dis. 2021;11(4):504-529
  17. Valera B, Sohani Z, Rana A, Poiri-er P, Anand SS. The ethnoepidemi-ology of obesity. Can J Cardiol. Feb 2015;31(2):131-41. doi:10.1016/j.cjca.2014.10.005

Published

2024-09-30

Issue

No. 3 (2024)

Section

Статьи