7. Assessment Of The Safety And Clinical Efficacy Of The Painkiller Rubufin In Surgical Patients In The Postoperative Period

Authors

  • T.K. Kuandykov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • V.V. Mutagirov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • A.P. Tungushbaev National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • A.T. Mahatov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • N.A. Alimanov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • S.T. Sherbaev National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • K.I. Dosymbetov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • K.T. Musadilov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • E.K. Kudajbergenov National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • B.Zh. Rahmanberdi National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan

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Abstract

Rubufin was applied in patients of the National Scientific Center of Surgery named after A. N. Syzganov in the postoperative period. Studied 150 patients aged 22 to 65 years. The effectiveness of anesthesia was assessed by changing the following criteria: blood pressure, pulse, heart rate, oxygen saturation in periph-eral blood, gas composition and acid-base state of the blood, and a visual analogue pain rating scale. The effect of rubufin on changes in blood biochemical parameters was studied. A decrease in pain syndrome was revealed by 1.5 times, a decrease in heart rate from 95.6 ± 8.8 to 83.2 ± 11.7 per minute, and respira-tory rate from 22.4 ± 2.7 to 16.3 ± 2.1 in minute, a decrease in mean arterial pressure is proportional to a decrease in pain, absence of respiratory depression, an increase in oxygen tension in the blood from 109.5 ± 23.4 mm Hg. up to 112.4 ± 16.6 mm Hg, no changes in blood biochemical parameters when using rubufin. Thus, it has been proven to be highly effective in anesthetizing patients with moderate and severe pain syn-drome after extensive surgical interventions, and to improve the indicators of blood oxygenation and stroke volume associated with the elimination of pain syndrome.

Keywords

postoperative pain, opioid receptor antagonist-agonists

References

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Published

2020-12-01

Issue

No. 4 (2020)

Section

Статьи