8. Prognostic Clinical Significance Of Myeloid Suppressor Cells And T Regulatory Cells In Sepsis (Review)

Authors

  • A.T. Aubakirova National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • G.B. Abdilova National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • K. Kataeva National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • D. Tartipkyzy National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • N.A. Davenova National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • A.N. Nurgalieva National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan
  • G.B. Dakenova National Scientific Center of Surgery named after A.N. Syzganov, Almaty, Kazakhstan

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Abstract

Modern medicine has made a great stride forward, but despite all the achievements, the problem of finding reliable criteria, concepts, definitions of sepsis remains relevant. Sepsis is potentially fatal in nature. The pronounced biological and clinical heterogeneity of patients with sepsis: age, premorbid background, drugs taken, different sources of infection create a high variability in the onset and course of the pathologi-cal process. New definitions of sepsis have refocused the focus on rethinking the clinical manifestations of this syndrome and have emphasized the importance of organ dysfunction as a key diagnostic feature. An unexplained organ failure in a patient should alert the physician to the possibility of sepsis. And the final result will depend on how quickly we can respond to changes, rationally and targeted therapy. The reasons for the dysregulation of the body’s response and delayed return to homeostasis in patients with sepsis are poorly understood. Growing interest is focused on a subpopulation of leukocytes called myeloid suppressor cells (MDSC). MDSC are involved in the regulation of the immune response in many pathological situations, the most studied of which is cancer. A number of comprehensive reviews have discussed MDSC in the context of cancer, autoimmunity, and infectious diseases. Interestingly, recent evi-dence suggests that MDSC are involved in the immune dysfunctions seen in sepsis. T regulatory cells

Keywords

sepsis, myeloid suppressor cells

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Published

2021-05-21

Issue

No. 1 (2021)

Section

Статьи