7. The use of cellular technologies in the complex treatment of purulent-septic wounds

Authors

  • K.R. Rustemova —
  • S.K. Kozhakhmetov —
  • S.S. Saparbaev —
  • A.U. Ismatov —
  • N.N. Tursynbaev —
  • S.Zh. Zhylkaidar —

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Abstract

Treatment of complicated forms of purulent wounds is an actual problem of modern medicine. A serious problem of the preoperative period is purulent complications that develop in 15-35% of cases, mortality reaches 25-60%. It is known that the predominant pathological syndrome in complicated forms of purulent sepsis is the syndrome of endogenous intoxication (SEI).

Objective. In this regard, the desire of many researchers to study new methods of intensive care for the syndrome of endogenous intoxication is understandable [1,2,3,4,5,5,6,7,8]. The authors analyzed the effectiveness of the use of mediators (surfactant) of fetal hepatocytes in the complex treatment of purulent-septic wounds.

Material and methods. A prospective study method was carried out for the main group, which consisted of patients with purulent-septic wounds (PSW) - 50 people, in the complex treatment of which cellular mediators (CM) were used; control group - 50 patients with PSW treated according to the traditional scheme.

Results. The results of treatment with cellular mediators were evaluated in 50 patients who received this drug at a dose of 0.15 ml/kg. The control group consisted of 50 patients who received saline at a dose of 0.15 ml/kg as a placebo. Men 27, women 23. The study was conducted in accordance with the Clinical Protocol for Surgical and Diagnostic Intervention of Transplantation of Fetal Cell Mediators Recommended by the Expert Council of the RSE on REM «Republican Center for Health Development» of the Ministry of Health and Social Development of the Republic of Kazakhstan dated September 30, 2015 (Protocol №. 10).

Conclusion. The results of the study have been implemented in the practice of the PKP on the REM of the Nur-Sultan MCH №2 and the Nur-Sultan MCH №1 ; highlighted in the work of the poster session of the VII Congress of Surgeons of Kazakhstan with international participation in Almaty from 30.09.-01.10.2021. Received AC No. 18079 of the Republic of Kazakhstan dated May 27, 2021 (www. kazpatent.kz)

Keywords

cellular mediators, fetal hepatocytes, purulent-septic wounds

References

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  10. Ismatov A.U., Shakenov A.D., Saparbaev S.S., Rustemova K.R., Kozhakhmetov S.K.-Improving the results of complex treatment of patients with purulent-septic wounds by using mediators of fetal hepatocytes.- AC № 18079 RK dated 27.05.2021-(www.kazhatent.kz) Figure 5. TNFα in dynamics Figure 6. Wound healing rate of the main group Figure 7. Wound healing rate of the control group

Published

2022-03-02

Issue

No. 1 (2022)

Section

Статьи