K. Nurgaliyeva

https://orcid.org/0000-0002-9604-7991

Найдено статей: 1

  • Distribution of high-risk human papillomavirus genotypes and their association with cervical cytology in Kazakhstani women (Выпуск № 2, 2025)

    N.* Kadroldinova, T. Ukybassova, B. Primbetov, B. Imankulova, S. Makhambetova, M. Galym, A. Batpanova, D. Baktybayeva, K. Nurgaliyeva, Z. Zhumakanova, K. Kongrtay, N. Kamzayeva
    2025-06-30
    67–80
    Аннотация

    Background. Precancerous lesions of the cervix in women of reproductive age are an urgent problem of modern medicine. Despite progress in understanding the molecular mechanisms of human papillomavirus mediated carcinogenesis and the introduction of screening and vaccination programs, the incidence of cervical cancer remains high worldwide. The aim of this study is to identify the prevalence and distribution of different cervical precancerous lesions. Materials and method. This is a cross-sectional study based on the University cluded 403 women of reproductive age (18-45 years). Two statistical analyses were used to compare differences between groups: the Kruskal–Wallis test and the Jonckheere– Terpstra test.

    Results. Age of the patients, Body Mass Index, age at menarche and other variables are distributed similarly among different precancerous lesion groups, suggesting homogeneous distribution of study population among cervical cytological groups. Overall, 35.1% of patients were tested positive for high-risk human papillomavirus in our cohort. Among 12 high risk human papillomavirus genotypes, ems-16 was the most prevalent high-risk human papillomavirus genotype with prevalence of 11.4%, followed by emsRO with a prevalence of 6.6% each other and ems-33 that was present in 5.3% patients who tested positive for human papillomavirus.

    Conclusion. among other Asian countries and underscores the value of ongoing regional surveillance to inform effective vaccination and screening policy.

    Ключевые слова

    Human papillomavirus, cervical precancerous lesions, cervical cancer, high-risk HPV genotypes