8. The role of the cervicovaginal microbiome and local immunity in human papillomavirus persistence and precancerous cervical changes

Авторы

  • M. Bekbossynova University Medical Center Corporate Fund, Astana, Kazakhstan
  • G. Myrzakhmetova University Medical Center Corporate Fund, Astana, Kazakhstan
  • S. Seitkasym University Medical Center Corporate Fund, Astana, Kazakhstan
  • A. Sailybaeva University Medical Center Corporate Fund, Astana, Kazakhstan
  • S. Khamitov University Medical Center Corporate Fund, Astana, Kazakhstan
  • K. Akzholova Nazarbayev University, Astana, Kazakhstan

Загрузки

Аннотация

Background. Metabolically associated fatty liver disease is closely linked to dyslipidemia and cardiovascular disease but the role of triglycerides as predictors of metabolically associated fatty liver disease severity remains underexplored.

Purpose. This study aimed to evaluate the association between triglyceride levels and hepatic steatosis and ʖbrosis LQ patients DW high cardiovascular risk

Methods. A total of 284 patients with cardiovascular disease and suspected metabolically associated fatty liver disease underwent clinical evaluation lipid proʖling and non-invasive liver assessment via Fibroscan. Spearman correlation analysis was used WR H[plore relationships between triglycerides liver steatosis ʖbrosis and lipid parameters.

Results. Triglycerides showed a modest positive correlation with hepatic steatosis U and D weaker correlation with ʖbrosis U Additionally triglycerides correlated moderately with total cholesterol U and low density lipoprotein cholesterol U 1R signiʖcant VH[ differences LQ liver disease stages were found

Conclusion. Triglycerides may serve as accessible biomarkers for early metabolically associated fatty liver disease related liver changes in cardiovascular patients. Further research is needed to validate their clinical utility. '2, %6. ,, Bekbossynova M.

Ключевые слова

metabolically, associated, fatty, liver, disease, low-density, lipoproteins, triglycerides, cardiovascular, diseased

Библиографические ссылки

  1. Semova I, Biddinger SB. Triglycerides LQ1RQDOFRKROLF)DWW/LYHU'LVHDVH Guilty Until Proven Innocent. Trends 3KDUPDFRO6FL0DU GRLMWLSV
  2. Fan N, Peng L, Xia Z, et al. Tri-glycerides to high-density lipopro-tein cholesterol ratio as a surrogate IRUQRQDOFRKROLFIDWWOLYHUGLVHDVHD cross-sectional study. Lipids Health 'LV)HE GRL s12944-019-0986-7
  3. Bril F, Barb D, Portillo-Sanchez P, et al. Metabolic and histologi-cal implications of intrahepatic tri-glyceride content in nonalcoholic fatty liver disease. Hepatology. Apr GRL hep.28985
  4. Zhang S, Du T, Zhang J, et al. The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease. Lip-LGV+HDOWK'LV-DQ GRLV
  5. Lee SB, Kim MK, Kang S, et al. Tri-glyceride Glucose Index Is Superior to the Homeostasis Model Assess-ment of Insulin Resistance for Pre-dicting Nonalcoholic Fatty Liver Dis-ease in Korean Adults. Endocrinol 0HWDE 6HRXO -XQ GRL(Q0
  6. Catanzaro R, Selvaggio F, Sciuto M, et al. Triglycerides to high-density lipo-protein cholesterol ratio for diagnos-ing nonalcoholic fatty liver disease. Minerva Gastroenterol (Torino). Sep GRL S2724-5985.21.02818-X
  7. Carlier A, Phan F, Szpigel A, et al. Dihydroceramides in Triglycer-ide-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Dis-ease Severity in Type 2 Diabetes. Cell 5HS 0HG 'HF GRLM[FUP
  8. Chen Z, Qin H, Qiu S, Chen G, Chen Y. Correlation of triglyceride to high-density lipoprotein cholester-ol ratio with nonalcoholic fatty liver disease among the non-obese Chi-nese population with normal blood OLSLG OHYHOV D UHWURVSHFWLYH FRKRUW research. Lipids Health Dis. Aug 9 GRLV 019-1104-6
  9. Abdelbasset WK, Tantawy SA, Ka-mel DM, Alqahtani BA, Soliman GS. A randomized controlled trial on the effectiveness of 8-week high-in-tensity interval exercise on intrahe-patic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonal-coholic fatty liver disease. Medicine %DOWLPRUH0DU H GRL0'
  10. Cheng Y, Zhang Q, Li H, et al. Rem-nant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver dis-ease. Front Endocrinol (Lausanne). GRLIHQ-do.2023.1098078
  11. Marchesini G, Bugianesi E, For-lani G, et al. Nonalcoholic fatty liv-er, steatohepatitis, and the meta-%8//(7,12)685*(5<,1.$=$.+67$1ɫ 87 bolic syndrome. Hepatology. Apr GRL jhep.2003.50161
  12. Xing J, Guan X, Zhang Q, Chen S, Wu S, Sun X. Triglycerides Mediate Body Mass Index and Nonalcoholic Fatty /LYHU 'LVHDVH $ 3RSXODWLRQ%DVHG 6WXG 2EHV )DFWV GRL
  13. Ling Q, Chen J, Liu X, et al. The tri-glyceride and glucose index and risk of nonalcoholic fatty liver dis-HDVH $ GRVHUHVSRQVH PHWDDQDO-ysis. Front Endocrinol (Lausanne). GRLIHQ-do.2022.1043169
  14. Kitae A, Hashimoto Y, Hamaguchi M, Obora A, Kojima T, Fukui M. The Tri-glyceride and Glucose Index Is a Pre-dictor of Incident Nonalcoholic Fatty /LYHU 'LVHDVH $ 3RSXODWLRQ%DVHG Cohort Study. Can J Gastroenter-RO +HSDWRO GRL
  15. Wang R, Dai L, Zhong Y, Xie G. Useful-ness of the triglyceride glucose-body mass index in evaluating nonalco-KROLF IDWW OLYHU GLVHDVH LQVLJKWV from a general population. Lipids +HDOWK 'LV -XO GRLV
  16. Li W, Wang Y, He F, et al. Association between triglyceride-glucose index and nonalcoholic fatty liver disease in type 2 diabetes mellitus. BMC En-GRFU 'LVRUG 2FW GRLV
  17. Zheng R, Du Z, Wang M, Mao Y, Mao W. A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease. Lipids Health Dis. 1RY GRL s12944-018-0913-3
  18. Khamseh ME, Malek M, Abbasi R, Taheri H, Lahouti M, Alaei-Shah-miri F. Triglyceride Glucose Index and Related Parameters (Triglycer-ide Glucose-Body Mass Index and Triglyceride Glucose-Waist Cir-cumference) Identify Nonalcohol-ic Fatty Liver and Liver Fibrosis in ,QGLYLGXDOV ZLWK 2YHUZHLJKW2EH-sity. Metab Syndr Relat Disord. Apr GRL met.2020.0109

Опубликован

2025-06-30

Выпуск

№ 2 (2025)

Раздел

Статьи