A. Djumabekov

https://orcid.org/0000-0002-3502-4411

Articles found: 2

  • Fatty liver disease after pancreatoduodenectomy and total pancreatectomy (Issue № 1, 2025)

    S. Tileuov, A. Dzhumabekov, B. Baimakhanov, M. Doskhanov, S. Kaniyev, J. Ospan, Y. Yenin, M. Tursynbai
    2025-03-31
    20–28
    Abstract

    Pancreatoduodenectomy is the only treatment method for patients with pancreatic head and periampullary region tumors. It is known that some long-lived patients develop exocrine pancreatic insufficiency after surgery. One of the consequences of exocrine pancreatic insufficiency is fatty liver disease, which has been reported to occur in 7.8% to 40.0% of patients after pancreatoduodenectomy. We reported two clinical cases of patients who underwent pancreatoduodenectomy and total pancreatectomy for pancreatic head cancer and intraductal papillary mucinous neoplasm of the main pancreatic duct. After surgery, they developed rapidly progressive fatty liver disease with no history of liver disease, leading to death from liver failure 20 days and 3 months after surgery. Severe malnutrition caused by exocrine pancreatic insufficiency, postoperative eating disorders, and exacerbation of diabetes mellitus were the main factors contributing to the rapid deterioration of the condition. This clinical case highlights the possibility of developing life-threatening fatty liver disease with severe fibrosis after pancreatoduodenectomy and total pancreatectomy. Careful monitoring of liver status, regular nutritional assessment of patients, prophylactic replacement of pancreatic enzymes, and ensuring adequate nutrition are important.

    Keywords

    pancreatoduodenectomy, fatty liver disease, pancreatic cancer, liver failure, exocrine pancreatic insufficiency

  • Surgical treatment of atrial fibrillation using cryoablation (Issue № 4, 2024)

    Z. Nurbay, R. Tuleutayev, R. Kuanishbekova, A. Djumabekov, D. Yestayev
    2024-12-31
    4–11
    Abstract

    Background. This study presents the results of a clinical trial evaluating the effectiveness of surgical treatments for atrial fibrillation in patients with rheumatic mitral valve disease. Special attention is given to the comparison of cryoablation and radiofrequency ablation, two methods used in conjunction with mitral valve surgeries. The results indicate that cryoablation, a method first used in Kazakhstan, has long-term advantages for restoring sinus rhythm and cardiac remodeling, thereby improving patients' quality of life. Materials and

    Methods. The study was conducted at the period from January 2020 to March 2024 through a retrospective analysis of data from patients with atrial fibrillation and rheumatic mitral valve disease who underwent surgical treatment using one of two methods: Cryoablation with left atrial appendage clipping (Group I) – 50 patients; Radiofrequency ablation with left atrial appendage suturing (Group II) – 50 patients.

    Results. According to the conducted research, both cryoablation and radiofrequency ablation are highly effective in restoring sinus rhythm in patients with atrial fibrillation and rheumatic mitral valve disease. Cryoablation, a procedure that was used for the first time in Kazakhstan, demonstrated significant advantages in the long-term maintenance of sinus rhythm and improvement in heart remodeling parameters, such as left atrial volume. This has enhanced the quality of life for patients. Conclusions. There is a need for the widespread implementation of innovative treatments for atrial fibrillation, such as cryoablation, as surgical procedures are more effective and patients with severe cardiovascular diseases have better outcomes.

    Keywords

    Atrial fibrillation, cryoablation, radiofrequency ablation, rheumatic mitral valve disease, sinus rhythm, surgical treatment of arrhythmias