D.R. Kurbanov

https://orcid.org/0000-0002-0426-9387

Табылған мақалалар: 2

  • Bile Duct Atresia. Literature Review (Шығарылым № 3, 2025)

    Biliary atresia, Z.U. diagnosis, Bakhytzhan Shirtayev, Kurbanov Doniyor, Azadbekova Zarnigora, Subhash Gupta
    2025-09-30
    96–114
    Аңдатпа

    Biliary atresia is a rare but severe congenital disease characterized by progressive obstruction of the extrahepatic and intrahepatic bile ducts and leading to cholestasis, fibrosis and cirrhosis of the liver in newborns. Epidemiological data demonstrate the variability of prevalence in different regions, which indicates the possible influence of genetic and environmental factors. The pathogenesis of the disease remains the subject of active study and includes the interaction of immune, viral and molecular mechanisms leading to damage to the bile ducts. Clinical diagnosis is difficult due to non-specific symptoms such as jaundice, light feces, and dark urine, which makes early detection critical to improve outcomes. Surgical intervention, known as Kasai surgery, remains the main treatment method and is aimed at restoring bile outflow, however, a significant proportion of patients eventually require liver transplantation. Current research focuses on the search for biomarkers for early diagnosis, the study of molecular targets, and the development of innovative therapeutic approaches, including immunomodulation and cellular technologies. The literature data emphasize the need for an integrated approach to disease management and further scientific research to improve clinical outcomes.

    Кілт сөздер

    Biliary atresia, diagnosis, screening, cytomegalovirus, portoenterostomy, Kasai, liver, transplantation, immunology, immunosuppression

  • Combined surgery of lung echinococcosis (Шығарылым № 4, 2024)

    B.K. Shirtayev, S.A. Kaniyev, G.N. Ismailova, N.Zh. Yerimova, D.R. Kurbanov, M.G. Aitzhanov, N.N. Rakhman
    2024-12-31
    25–33
    Аңдатпа

    Background. Pulmonary cystic echinococosis, a parasitic disease, is a health care problem in developing countries. In this study, we evaluated outcomes of patients with pulmonary hydatid disease who were treated in our department.Study was performed to compare results of surgical treatment and complications of patients with unilateral or bilateral thoracic and combined pulmonary cystic echinococosis.

    Methods. This cross-sectional analysis of a prospective study was conducted in the Department of Thoracic and Pediatric Surgery, Scientific Center of Surgery, Almaty, Kazakhstan among 598 patients with pulmonary cystic echinococosis, who had surgical treatment with various surgical methods, depending on the prevalence of echinococcosis, as follows: right lung in 357 (59.5%) patients, left lung in 243 (40.5%) patients, bilateral in 95 (15.8%) patients, and complicated echinococcosis in 317 (52.8%) patients. Length of stay per hospital stay has been decreased (p 0.0001) by video-thoracoscopicechinococcectomy with the high-energy laser treatment of cyst, than after echinococcectomy by cyst treatment with povidone-iodine. Treatment with formalin presented the longest hospital stay (p 0.0001).

    Results. Comparative analysis of patients with uncomplicated and complicated pulmonary cystic echinococosis showed a high frequency of postoperative complications associated with complicated echinococcosis (OR = 2.2, p 0.0001).

    Conclusion. Despite the success of surgical treatment of pulmonary cystic echinococosis, issues of intraoperative dissemination and safety remain, and treatment success rates can be improved. These factors require further prospective multicenter studies.

    Кілт сөздер

    pulmonary cystic echinococosis, video- assisted thorascopicechinococcectomy, bilateral echinococcosis, transmedistinal access, combined echinococcosis